Mahabharata 12.170.21

तेषां परमदुःखानां बुद्ध्या भैषज्यमाचरेत्लोकधर्मं समाज्ञाय ध्रुवाणामध्रुवैः सह

teṣāṃ paramaduḥkhānāṃ buddhyā bhaiṣajyamācaretlokadharmaṃ samājñāya dhruvāṇāmadhruvaiḥ saha

Our plain-language meaning of this verse is waiting for scholar review.